A. Clinton White Jr, MD; Susan M. Miller, MD, MPH
To the Editors: There has been widespread acceptance of offering zidovudine prophylaxis to medical staff who have had needlestick exposure to the human immunodeficiency virus (HIV) (1). We feel that too little attention has been paid to the potential risks and benefits of attempted prophylaxis. The article (2) and accompanying editorial (3) in a recent issue provide insights into the risk accompanying these exposures. As pointed out, most seroconversions followed deep intramuscular exposure or deep cuts. On the basis of the proportion of exposures due to simple needlesticks in Henderson and colleagues' study (170 of 179) and the number of
White AC, Miller SM. HIV Infection after Needlesticks. Ann Intern Med. ;114:253. doi: 10.7326/0003-4819-114-3-253_1
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Published: Ann Intern Med. 1991;114(3):253.
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