Stephen L. Scheeler, MD
To the Editors: In their study of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis and systemic vasculitis, Falk and associates (1) conclude that "therapy with either intravenous cyclophosphamide or oral cyclophosphamide is effective in patients with renal-limited disease as well as in those with glomerulonephritis and alveolar hemorrhage." In their experience, intravenous cyclophosphamide had proved to be a reliable and efficacious therapy.
These findings are at odds with those of Hoffman and co-workers (2), who did a study of pulse intravenous cyclophosphamide as therapy for Wegener granulomatosis. These investigators noted an initial high percentage of responders.
However, the long-term failure rate was
Stephen L. Scheeler. Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis. Ann Intern Med. 1991;114:430–431. doi: 10.7326/0003-4819-114-5-430
Download citation file:
Published: Ann Intern Med. 1991;114(5):430-431.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use