Romain K. Gherardi, MD; Denis Malapert, MD; Jean-Denis Degos, MD
To the Editors: Feigert and colleagues (1) have described an unusual association between multicentric angiofollicular lymph node hyperplasia (AFLNH) (multicentric Castleman disease) and a unique clinical syndrome of peripheral neuropathy, pseudotumor cerebri, IgA dysproteinemia, and thrombocytosis in four women. The authors assume that this symptom complex represents a distinct clinicopathologic entity taking a place among the various conditions in which AFLNH may be observed. They admit that there may be some relation between the complex and the POEMS (or Crow-Fukase) syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) (2), but none of their patients showed the complete form of
Gherardi RK, Malapert D, Degos J. Castleman Disease-POEMS Syndrome Overlap. Ann Intern Med. ;114:520–521. doi: 10.7326/0003-4819-114-6-520
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Published: Ann Intern Med. 1991;114(6):520-521.
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