Moshe Talpaz, MD; Hagop Kantarjian, MD; Razelle Kurzrock, MD; Jose M. Trujillo, MD; Jordan U. Gutterman, MD
Objectives: To evaluate the frequency and the course of complete cytogenetic responses in interferon-alpha (IFN-α)-treated patients with chronic myelogenous leukemia.
Design: Two prospective trials in consecutive patients.
Setting: A major tertiary cancer center.
Patients: Ninety-six consecutive patients with chronic myelogenous leukemia with disease duration of less than 1 year.
Intervention: Patients received partially pure IFN-α intramuscularly, from 3 to 9 million U/d (51 patients) or recombinant IFN-α2a (Roferon, Hoffmann-LaRoche, Inc., Nutley, New Jersey), 5 million U/m2 body surface area daily (45 patients).
Measurements: Hematologic and cytogenetic tests were administered.
Main Results: Seventy of the patients (73%) achieved hematologic remission (95% CI, 63% to 81%), and 18 (19%) had complete suppression of the Philadelphia chromosome on at least one cytogenetic test. A complete cytogenetic response was induced in 7 of 51 or 14% (CI, 6% to 26%) of the patients treated with the partially pure IFN-α and in 11 of 45 or 24% (CI, 13% to 40%) of the patients treated with recombinant IFN-α2a. The difference in complete cytogenetic response between the two groups was 10.7% (CI, - 5% to 26%; P > 0.2). Eleven patients had durable, ongoing, complete cytogenetic responses from 6 to more than 45 months (median, more than 30 months).
Conclusion: This study was the first to show sustained, complete cytogenetic responses in a subset of patients with chronic myelogenous leukemia treated with single-agent therapy. The nature of this remission, that is, whether it depends on continuous therapy, requires further study.
Moshe Talpaz, Hagop Kantarjian, Razelle Kurzrock, Jose M. Trujillo, Jordan U. Gutterman. Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia: Philadelphia Chromosome-Positive Patients. Ann Intern Med. 1991;114:532–538. doi: 10.7326/0003-4819-114-7-532
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Published: Ann Intern Med. 1991;114(7):532-538.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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