J. L. Ambrus, MD, PhD; K. C. Chadha, PhD; J. L. Ambrus Jr., MD
To the Editors: In previous reports, we described nonantibody-type interferon inhibitors in patients with systemic lupus erythematosus (1). We are in the process of isolating and identifying these inhibitors and of studying their mechanisms of action. Similar inhibitors were found in the circulation in patients with some neoplastic and viral diseases including the acquired immunodeficiency syndrome (AIDS) (2-4). These inhibitors were not found in normal persons.
We have recently studied a patient with advanced, biopsy-proved Wegner granulomatosis and vasculitis. Using previously reported methods to assay interferon inhibitory activity (3, 4), we found that this patient had 35 Roswell Park Memorial
Ambrus JL, Chadha KC, Ambrus JL. Interferon Inhibitors. Ann Intern Med. ;114:606–607. doi: 10.7326/0003-4819-114-7-606_2
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Published: Ann Intern Med. 1991;114(7):606-607.
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