Philippe Deloron, MD; Jean Paul Lepers, MD; Lucie Raharimalala, MD; Béatrice Dubois, MA; Pierre Coulanges, MD; Jean Jacques Pocidalo, PhD
The spread of chloroquine-resistant Plasmodium falciparum strongly indicated the need for new safe and effective antimalarial drugs. In addition to their antibacterial action, fluoroquinolone antibiotics inhibit P. falciparum in vitro (1). Pefloxacin is effective against P. yoelii infection in mice (2), and norfloxacin, the main metabolite of Pefloxacin in humans, was reported to cure P. falciparum malaria in 9 adults in India (3). Therefore, we assessed the efficacy of Pefloxacin in treating chloroquine-resistant P. falciparum malaria in Madagascar (4).
In Ankazobe, 95 km west of Antananarivo, the capital of Madagascar, blood was collected from 396 adults to
Deloron P, Lepers JP, Raharimalala L, Dubois B, Coulanges P, Pocidalo JJ. Pefloxacin for Falciparum Malaria: Only Modest Success. Ann Intern Med. ;114:874–875. doi: 10.7326/0003-4819-114-10-874
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Published: Ann Intern Med. 1991;114(10):874-875.
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