Nand K. Wadhwa, MD; Harold Atkins, MD; Thelma Cabralda, RN
To the Editors: Erythromycin appears to be a gastric prokinetic agent, which probably binds to motilin receptors and acts as a motilin agonist (1, 2). Erythromycin has recently been reported to improve gastric emptying in patients with gastroparesis associated with diabetes mellitus and progressive systemic sclerosis (3, 4). We report the case of a diabetic patient on continuous ambulatory peritoneal dialysis in whom intraperitoneal administration of erythromycin was effective in relieving vomiting from gastroparesis.
A 41-year-old woman developed end-stage renal disease secondary to diabetic nephropathy and had been on continuous ambulatory peritoneal dialysis since July 1988. She has had insulin-dependent
Wadhwa NK, Atkins H, Cabralda T. Intraperitoneal Erythromycin for Gastroparesis. Ann Intern Med. ;114:912. doi: 10.7326/0003-4819-114-10-912_1
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Published: Ann Intern Med. 1991;114(10):912.
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