Layne O. Gentry, MD
During the past several years, antimicrobial agents have been developed that can be administered orally, are active against the spectrum of organisms that cause osteomyelitis, and are relatively nontoxic when administered over a prolonged period. The most important among these agents are the oral fluoroquinolones, which include ciprofloxacin and ofloxacin in the United States and Pefloxacin in Europe. These agents penetrate bone at sufficient concentrations to inhibit most strains of Staphylococcus aureus, Enterobacteriaceae, and Pseudomonas aeruginosa (1).
Chronic, or recurrent, osteomyelitis has been principally caused by staphylococci. Carefully conducted trials in 1968 and 1976 have shown that high-dose oral penicillin
Gentry LO. Oral Antimicrobial Therapy for Osteomyelitis. Ann Intern Med. ;114:986–987. doi: 10.7326/0003-4819-114-11-986
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Published: Ann Intern Med. 1991;114(11):986-987.
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