Luis Fernandez-Herlihy, MD
To the Editors: The time has come to stop the use of injectable (or any other) gold in the treatment of adult rheumatoid arthritis. The recent report by Epstein and colleagues (1) on the apparent ineffectiveness of parenteral chrysotherapy is highly significant. Since the first reports of the use of gold therapy in rheumatoid arthritis, 64 years ago, its efficacy has been hotly debated and its toxicity has been amply documented. A recent study (2) found that of six commonly used second-line drugs for the treatment of rheumatoid arthritis (methotrexate, injectable gold, D-penicillamine, sulfasalazine, auranofin, and antimalarials), injectable gold had
Fernandez-Herlihy L. Requiem for Gold?. Ann Intern Med. 1991;114:993–994. doi: 10.7326/0003-4819-114-11-993_3
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Published: Ann Intern Med. 1991;114(11):993-994.
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