Kanwar Singh, MD; G. Dennis Shanks, MD; Henry Wilde, MD
To the Editors: Mefloquine, 250 mg weekly starting 1 week before travel and ending 4 weeks after departure from areas in which malaria is endemic, has been recommended in the United States for prophylaxis in travelers to areas where chloroquine-resistant falciparum malaria has been reported (1). Although minor side effects, such as dizziness and vomiting, were commonly reported in a placebo-controlled, double-blinded trial in U.S. soldiers deployed to Thailand, weekly mefloquine was generally well tolerated (2). A study of 3386 European tourists returning from Africa who received mefloquine indicated only one possibly drug-related reaction (depression), and there were no reports
Singh K, Shanks GD, Wilde H. Seizures after Mefloquine. Ann Intern Med. ;114:994. doi: 10.7326/0003-4819-114-11-994_1
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Published: Ann Intern Med. 1991;114(11):994.
Neurology, Seizure Disorders.
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