Stephen M. Capon, MD; William D. DePond, MD; Dolly B. Tyan, MA; Samuel H. Pepkowitz, MD; Hiroo Toyoda, PhD; Arnold C. Cinman, MD; Paul C. Azer, MD; Dennis Goldfinger, MD
Transfusion-associated graft-versus-host disease (TAGVHD) is a rare complication of transfusion (1) that occurs when immunocompetent donor lymphocytes attack host tissues expressing foreign histocompatibility antigens. Until recently, it was believed that only transfusion recipients with profound defects in cellular immunity were susceptible to TA-GVHD. However, there have now been reports of TA-GVHD occurring in immunocompetent patients (2, 3). In each, one blood donor possessed an HLA phenotype consisting entirely of antigens shared by the recipient, whereas the recipient expressed additional HLA antigens not shared by the donor. Transfusion-associated graft-versus-host disease appeared to develop because recipient lymphocytes were genetically incapable of mounting
Capon SM, DePond WD, Tyan DB, Pepkowitz SH, Toyoda H, Cinman AC, et al. Transfusion-associated Graft-versus-Host Disease in an Immunocompetent Patient. Ann Intern Med. ;114:1025–1026. doi: 10.7326/0003-4819-114-12-1025
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Published: Ann Intern Med. 1991;114(12):1025-1026.
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