Antonella Surbone, MD; James O. Armitage, MD; Robert Peter Gale, MD, PhD
Although some persons with large-cell lymphoma are cured with chemotherapy, most are not. In persons failing to achieve an initial remission and in those relapsing, rescue is generally attempted with further chemotherapy or, in some cases, radiation. Unfortunately, results of rescue therapy are poor. Recently, in an attempt to improve this situation, very high doses of chemotherapy or radiotherapy (or both) were administered followed by an autotransplant of previously stored hematopoietic stem cells from bone marrow or blood. Early reports suggested a higher cure rate with the more intensive therapy that autotransplantation allowed.
There is now widespread interest in autotransplantation
Surbone A, Armitage JO, Gale RP. Autotransplantation in Lymphoma: Better Therapy or Healthier Patients?. Ann Intern Med. 1991;114:1059–1060. doi: 10.7326/0003-4819-114-12-1059
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Published: Ann Intern Med. 1991;114(12):1059-1060.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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