Gregory S. Holt, MD; James L. Wofford, MD; Ramon Velez, MD
To the Editors: Assays for hemoglobin (Hgb) A1C are considered by some to be the "gold standard" for monitoring long-term glycemic control in diabetic patients (1). Various techniques are currently available to measure Hgb A1C, including chromatography (column ion-exchange, liquid, affinity, minicolumn), electrophoresis (isoelectric focusing), and colorimetric methods. These methods have been shown to have reasonable precision. However, ion-exchange chromatography, a popular and relatively inexpensive technique, seems to be affected by hemoglobin variants (2). A falsely elevated Hgb A1C by this method may occur in patients with increased Hgb F or beta-thalassemia, whereas falsely low results may occur when Hgb
Holt GS, Wofford JL, Velez R. Hemoglobinopathies Affect Hemoglobin A1C Measurement. Ann Intern Med. ;115:68–69. doi: 10.7326/0003-4819-115-1-68_2
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Published: Ann Intern Med. 1991;115(1):68-69.
Hematology/Oncology, Red Cell Disorders.
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