Robert P. Perrillo, MD; Elizabeth M. Brunt, MD
The treatment of chronic hepatitis B with recombinant alpha-interferon results in the disappearance of hepatitis B e antigen (HBeAg) and hepatitis B virus DNA (HBV DNA) from serum in nearly 40% of patients (1, 2). In addition, hepatitis B surface antigen (HBsAg) seroconversion occurs in approximately one third of responders (2). Improvement in serum aminotransferase levels and partial resolution of hepatic inflammation have been seen in most responders when evaluated 6 to 12 months after the completion of therapy (2-4). Whereas recent data indicate that the disappearance of serum markers for viral replication and improvement in liver function are often
Perrillo RP, Brunt EM. Hepatic Histologic and Immunohistochemical Changes in Chronic Hepatitis B after Prolonged Clearance of Hepatitis B e Antigen and Hepatitis B Surface Antigen. Ann Intern Med. ;115:113–115. doi: 10.7326/0003-4819-115-2-113
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Published: Ann Intern Med. 1991;115(2):113-115.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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