Matthew B. Smith, MD
To the Editors: In their recent article, Ezzat and colleagues (1) report the results of a prospective colonoscopic study of 23 acromegalic patients. Eight (35%) of these patients were found to have adenomatous polyps. The authors note that "this far exceeds the 12% (P < 0.01) frequency of polyps noted in normal persons." However, the study they cite as demonstrating the frequency of polyps in normal persons only estimated the prevalence of distal adenomas using a 60-cm sigmoidoscope (2).
A more reasonable comparison would be to a sample of asymptomatic persons undergoing screening colonoscopy. Such a prospective study was recently
Smith MB. Colonic Polyps in Acromegaly. Ann Intern Med. ;115:232–233. doi: 10.7326/0003-4819-115-3-232
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Published: Ann Intern Med. 1991;115(3):232-233.
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