Rodney H. Falk, MD
To the Editors: I thank Dr. Zatuchni for his comments on our recent article on digoxin for atrial fibrillation (1, 2). I believe, however, that he has both missed the point and failed to take its message to heart. Contrary to his statement, we do understand why digoxin has been popular for 200 years. Its effects on resting heart rate in atrial fibrillation—the most obvious property of the drug—can be dramatic. We stress, however, that the natural human state is not one of perpetual rest and therefore that observations in the office do not necessarily reflect the behavior of the
Falk RH. Digoxin: Mythology or Evidence?. Ann Intern Med. ;115:329. doi: 10.7326/0003-4819-115-4-329_1
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Published: Ann Intern Med. 1991;115(4):329.
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