Jacob Zatuchni, MD
To the Editors: Ellison (1), in his excellent study of diuretic resistance, does not consider its most common occurrence—the absence of diuresis with continued administration of a diuretic to a person with heart disease but whose heart failure has been dissipated. In the treatment of heart failure, continued daily administration of a diuretic is common practice to prevent recurrence of edema, attainment of dry weight notwithstanding. In such a circumstance, the body is resistant to the diuretic. The diuretic drug becomes paradoxically not only a salt-retaining agent, but also a stimulator of potentially noxious neurohormones. With subsidence or control of
Zatuchni J. Diuretic Resistance versus Adaptation. Ann Intern Med. ;115:408–409. doi: 10.7326/0003-4819-115-5-408
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Published: Ann Intern Med. 1991;115(5):408-409.
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