Malvinder S. Parmar, MD
To the Editors: Baclofen, a derivative of the inhibitory neurotransmitter gamma-aminobutyric acid, is useful for reducing frequency and severity of flexor or extensor muscle spasms (1). I report an unusual reaction in a patient with renal failure, who developed a state of "motionless, mindless wakefulness" after a single dose of baclofen. A 57-year-old woman with polycystic kidney disease and end-stage renal failure on maintenance hemodialysis was prescribed baclofen for muscle spasms unresponsive to conventional measures. After taking 10 mg of baclofen and 650 mg of acetaminophen, she fell asleep. Six hours later she was found to be unresponsive and was
Parmar MS. Akinetic Mutism after Baclofen. Ann Intern Med. 1991;115:499–500. doi: 10.7326/0003-4819-115-6-499_3
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Published: Ann Intern Med. 1991;115(6):499-500.
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