Adam F. Cohen, MD, PhD; Ria Kroon, BSc; Rik Schoemaker, MSc; Hans Hoogkamer, MSc; Anja van Vliet, SRN
▪ Objective: To study how changes in gastric acidity induced by omeprazole and pentagastrin affect the absorption of unchanged digoxin and its hydrolytic breakdown products.
▪ Design: Double-blind, double-dummy, randomized, crossover study.
▪ Setting: Academic department of clinical pharmacology.
▪ Subjects: Six healthy male volunteers.
▪ Interventions: Subjects received digoxin, 1 mg orally, on three separate occasions: first, after pretreatment with omeprazole; second, after pretreatment with pentagastrin; and third, after "pretreatment" with placebo.
▪ Measurements: The in-vitro decomposition of digoxin was studied using a standard dissolution test. The urinary excretion of digoxin over a 120-hour period was measured using selective high-pressure liquid chromatography (HPLC) and a polarization enzyme immunoassay (EIA). Plasma concentrations were measured at 2 hours with the EIA.
▪ Main Results: Digoxin was rapidly released from the tablets in the in-vitro test. At acid pH, decomposition (as measured with HPLC) was rapid. Pentagastrin reduced the urinary excretion of unchanged digoxin, as measured by HPLC, from 34% to 21.4% of the dose (difference, - 12.6%; 95% Cl, - 23.5 to - 1.8; P < 0.05), whereas omeprazole increased urinary excretion to 47.4% (difference, 13.4%; 95 Cl, 2.5% to 24.4%; P < 0.05). However, such differences were not found with the nonselective polarization EIA.
< Conclusions: Our data suggest that gastric acidity causes the breakdown of digoxin to products that cross-react in the assay (EIA) that is commonly used clinically. In patients with reduced gastric acidity, increased plasma concentrations of unchanged digoxin may not be detected because of limitations of the EIA, which may invalidate the quantitative use of the plasma digoxin concentration as a predictor of digoxin toxicity. Omeprazole, and presumably other gastric-acid inhibitors, may increase the bioavailability of unchanged digoxin.
Cohen AF, Kroon R, Schoemaker R, Hoogkamer H, van Vliet A. Influence of Gastric Acidity on the Bioavailability of Digoxin. Ann Intern Med. ;115:540–545. doi: 10.7326/0003-4819-115-7-540
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Published: Ann Intern Med. 1991;115(7):540-545.
Emergency Medicine, Hospital Medicine.
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