Lung T. Yam, MD; Socorro B. Oropilla, MD
To the Editors: The somatostatin analog octreotide acetate (Sandostatin, Sandoz Pharmaceuticals, East Hanover, New Jersey) has been used to treat diarrhea associated with various disorders (1). We report the successful use of octreotide to treat intractable diarrhea in a patient with amyloidosis secondary to multiple myeloma.
A 53-year-old man with multiple myeloma of the immunoglobulin G-kappa type was treated with melphalan-prednisone, and his hematologic status became stable. He was found to have polyneuropathy 14 months after the diagnosis of myeloma was made. Diarrhea, hepatomegaly, congestive heart failure, polyserositis, orthostatic hypotension, and periorbital bleeding were subsequently noted. Amyloidosis was diagnosed on
Yam LT, Oropilla SB. Octreotide for Diarrhea in Amyloidosis. Ann Intern Med. ;115:577. doi: 10.7326/0003-4819-115-7-577_1
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Published: Ann Intern Med. 1991;115(7):577.
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