Alvaro J. Lopez, MD; Paul O'Keefe, MD; Marilynn Morrissey; Jack Pickleman, MD
Gallbladder sludge formation has been reported as a unique complication of therapy with ceftriaxone. We report the first patient with proven ceftriaxone-induced cholelithiasis in which the drug was identified as the major component of the gallstone.
A 42-year-old man had a history of rheumatic heart disease and of chronic active hepatitis for which he was receiving prednisone. Between September 1989 and February 1990 he had three episodes of infective endocarditis with Salmonella group C1 (Salmonella choleraesuis). Each episode of endocarditis was treated with a prolonged (minimum, 7 weeks) course of intravenous ceftriaxone, 2 g every 12 hours, and
Lopez AJ, O'Keefe P, Morrissey M, Pickleman J. Ceftriaxone-induced Cholelithiasis. Ann Intern Med. ;115:712–714. doi: 10.7326/0003-4819-115-9-712
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Published: Ann Intern Med. 1991;115(9):712-714.
Biliary Disorders, Gastroenterology/Hepatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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