Manuel Rodríguez, MD; Luis Rodrigo, PhD; Francisco Tévar, MD
To the Editors: The first-generation enzyme-linked immunosorbent assay (ELISA) for hepatitis C virus (HCV), which detects antibodies against c-100 antigen, is positive in about 70% (1) and 75% (2) of patients with acute and chronic non-A, non-B hepatitis, respectively. Furthermore, using this assay, antibody detection in patients with acute non-A, non-B hepatitis is considerably delayed (3).
Recently, a second-generation ELISA was developed; it incorporates one antigen from the nonstructural NS3 and NS4 regions (c200) and a HCV-core-associated antigen (c22-3). We have evaluated this assay (Ortho Diagnostic Systems, Raritan, New Jersey) in patients with acute and chronic non-A, non-B hepatitis who
Rodríguez M, Rodrigo L, Tévar F. Second-Generation Tests for Hepatitis C Virus. Ann Intern Med. ;115:747–748. doi: 10.7326/0003-4819-115-9-747
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Published: Ann Intern Med. 1991;115(9):747-748.
Gastroenterology/Hepatology, Infectious Disease, Viral Hepatitis.
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