P. H. Chandrasekar, MD
To the Editors: Use of antimicrobial drugs as prophylaxis against infection during episodes of neutropenia in patients with cancer has remained controversial. A recent consensus report by the Working Committee of the Infectious Diseases Society of America stated that antibiotic prophylaxis should only be considered in afebrile patients at the highest risk for infection; that is, profound neutropenia (< 100 cells/µL) with an expected duration greater than 7 days (1). Prophylactic agents have included oral nonabsorbable drugs, trimethoprim-sulfamethoxazole, and quinolones. Oral nonabsorbable drugs such as gentamicin, vancomycin, and colistin became unpopular because of variable clinical success and poor patient compliance.
Chandrasekar PH. Quinolone Prophylaxis during Neutropenia. Ann Intern Med. ;115:833. doi: 10.7326/0003-4819-115-10-833_1
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Published: Ann Intern Med. 1991;115(10):833.
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