Charles F. Curran, PhD
To the Editors: Twelve accidental acute doxorubicin overdoses (range, 3 to 10 times intended dose) have been reported to Adria Laboratories (Columbus, Ohio) since 1977. Nine patients (75%) received doxorubicin as part of a multidrug regimen. Of these, three patients were also simultaneously overdosed with other antineoplastic agents. Eight patients (67%) were given overdoses during the first administration of doxorubicin.
Leukopenia or pancytopenia was universal. Mucositis, generally requiring 2 to 6 weeks for resolution, was reported in six of the seven (86%) patients who recovered, but in only one of the five (20%) patients who died. Two patients developed heart
Curran CF. Acute Doxorubicin Overdoses. Ann Intern Med. ;115:913–914. doi: 10.7326/0003-4819-115-11-913_2
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Published: Ann Intern Med. 1991;115(11):913-914.
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