John R. Roeback Jr., PhD; Khin Mae Hla, MD, MHS; Lloyd E. Chambless, PhD; Robert H. Fletcher, MD, MSc
▪ Objective: To determine the efficacy of glucose tolerance factor (GTF)-chromium for increasing serum levels of high-density lipoprotein (HDL) cholesterol in patients taking beta-blockers.
▪ Design: Randomized, double-blind, placebo-controlled trial.
▪ Setting: Mixed primary and referral-based outpatient clinic at a university-affiliated VA Medical Center.
▪ Patients: Referred sample of 72 men receiving beta-blockers, mainly for hypertension. Sixty-three patients (88%) completed the study.
▪ Interventions: Current medications, including beta-blockers, were continued. During the 8-week treatment phase, patients in the chromium group received a total daily dose of 600 µg of biologically active chromium divided into three equal doses; control patients received a placebo of identical appearance and taste.
▪ Measurements: Serum levels of total cholesterol and HDL cholesterol were measured.
▪ Main Results: Mean baseline levels of HDL and total cholesterol (± SD) were 0. 93 ± 0.28 mmol/L and 6.0 ± 1.0 mmol/L (36 ± 11.1 mg/dL and 232 ± 38.5 mg/dL), respectively. The difference between groups in adjusted mean change in HDL cholesterol levels, accounting for baseline HDL cholesterol levels, age, weight change, and baseline total cholesterol levels, was 0.15 mmol/L (5.8 mg/dL) (P = 0.01) with a 95% Cl showing that the treatment effect was > + 0.04 mmol/L (+ 1.4 mg/dL). Mean total cholesterol, triglycerides and body weight did not change significantly during treatment for either group. Compliance as measured by pill count was 85%, and few side effects were reported. Two months after the end of treatment, the between-group difference in adjusted mean change from baseline to end of post-treatment follow-up was - 0.003 mmol/L (- 0.1 mg/dL).
▪ Conclusion: Two months of chromium supplementation resulted in a clinically useful increase in HDL cholesterol levels in men taking beta-blockers.
John R. Roeback, Khin Mae Hla, Lloyd E. Chambless, Robert H. Fletcher. Effects of Chromium Supplementation on Serum High-Density Lipoprotein Cholesterol Levels in Men Taking Beta-Blockers: A Randomized, Controlled Trial. Ann Intern Med. 1991;115:917–924. doi: 10.7326/0003-4819-115-12-917
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Published: Ann Intern Med. 1991;115(12):917-924.
Cardiology, Coronary Risk Factors, Dyslipidemia, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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