Joseph J. Lieber, MD
To the Editors: The recent article by Lang and colleagues (1) highlights the potential difficulties in using intravenous contrast agents in patients receiving beta-blocker therapy. Certainly, anaphylactoid reactions could be difficult to treat given the beta-blockade and the importance of using beta-agonists to ameliorate this condition.
Glucagon, a polypeptide with diverse effects on the gastrointestinal tract (including the liver), plays a role in metabolic control. Glucagon raises cyclic adenosine monophosphate (AMP) levels via noncatecholamine mechanisms and therefore has direct inotropic properties. Furthermore, glucagon can release catecholamines from a pheochromocytoma and can be used to increase cardiac contractility, especially in the
Lieber JJ. Risk for Anaphylactoid Reaction from Contrast Media. Ann Intern Med. ;115:985. doi: 10.7326/0003-4819-115-12-985_1
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Published: Ann Intern Med. 1991;115(12):985.
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