Keith Henry, MD; Scott Rathgaber, MD; Christopher Sullivan, MD; Kathleen McCabe, RN
Megestrol acetate has been reported to be a relatively nontoxic drug (1, 2) that is efficacious in the treatment of cachexia associated with the acquired immune deficiency syndrome (AIDS) (3). We report the case of a patient with AIDS who developed diabetes mellitus requiring insulin therapy 13 weeks after beginning megestrol therapy and who experienced an exacerbation of his diabetes when rechallenged with megestrol.
A 46-year-old man had been diagnosed with AIDS 2.5 years earlier when a skin biopsy specimen showed Kaposi sarcoma. His treatment regimen is summarized in Figure 1. Before beginning therapy with megestrol acetate, his
Henry K, Rathgaber S, Sullivan C, McCabe K. Diabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and Cachexia. Ann Intern Med. ;116:53–54. doi: 10.7326/0003-4819-116-1-53
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Published: Ann Intern Med. 1992;116(1):53-54.
HIV, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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