Avrum Z. Bluming, MD; William J. M. Hrushesky, MD
To the Editors: In his editorial (1), Dr. McGuire concludes that he cannot be sure of any apparent benefit from timing of initial breast cancer surgery in relation to the patient's menstrual cycle because all published studies dealing with the question have been retrospective. He suggests that a properly designed prospective study be done to resolve this question. We suggested the same in our original 1989 article (2), and subsequently.
Dr. McGuire's witty argument, about the inevitability of statistically significant results due only to chance, is misleading. He neglects to mention that the hypothesis that surgical timing within the fertility
Bluming AZ, Hrushesky WJM. Optimal Timing of Initial Breast Cancer Surgery. Ann Intern Med. ;116:268–269. doi: 10.7326/0003-4819-116-3-268_2
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Published: Ann Intern Med. 1992;116(3):268-269.
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