Kenneth S. Weiss, MD
To the Editors: Nephrotic range proteinuria is a well-documented side effect of recombinant gamma interferon and all other interferons (1-3). The doses reported to cause this effect have been in the range of 0.25 mg/m2 to 1 mg/m2 body surface area (activity, 1 x 107 units per milligram of protein). I report a case of nephrotic-range proteinuria in a patient receiving therapy at a much lower dose.
A 64-year-old man had wide excision and skin grafting for a Clark level-IV (11.2 mm-thick) malignant melanoma on his midback. He soon thereafter developed axillary adenopathy, consistent with metastatic melanoma. He agreed to
Weiss KS. Nephrotic Range of Proteinuria and Interferon Therapy. Ann Intern Med. 1992;116:347. doi: 10.7326/0003-4819-116-4-347_1
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Published: Ann Intern Med. 1992;116(4):347.
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