Kenneth S. Weiss, MD
To the Editors: Nephrotic range proteinuria is a well-documented side effect of recombinant gamma interferon and all other interferons (1-3). The doses reported to cause this effect have been in the range of 0.25 mg/m2 to 1 mg/m2 body surface area (activity, 1 x 107 units per milligram of protein). I report a case of nephrotic-range proteinuria in a patient receiving therapy at a much lower dose.
A 64-year-old man had wide excision and skin grafting for a Clark level-IV (11.2 mm-thick) malignant melanoma on his midback. He soon thereafter developed axillary adenopathy, consistent with metastatic melanoma. He agreed to
Weiss KS. Nephrotic Range of Proteinuria and Interferon Therapy. Ann Intern Med. ;116:347. doi: 10.7326/0003-4819-116-4-347_1
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Published: Ann Intern Med. 1992;116(4):347.
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