Eileen Hilton, MD; Henry D. Isenberg, PhD; Phyllis Alperstein, DMT; Kenneth France, MS; Michael T. Borenstein, PhD
▪ Objective: To assess whether daily ingestion of yogurt containing Lactobacillus acidophilus prevents vulvovaginal candidal infections.
▪ Design: Crossover trial for at least 1 year during which patients were examined for candidal infections and colonizations while receiving either a yogurt-free or a yogurt-containing diet. Patients served as their own controls.
▪ Setting: Ambulatory infectious disease center in a teaching hospital providing tertiary care.
▪ Patients: Thirty-three women with recurrent candidal vaginitis were eligible after recruitment from community practices and clinics and through advertising. Twelve patients were eliminated for protocol violations. Of the remaining 21 patients, 8 who were assigned to the yogurt arm initially refused to enter the control phase 6 months later. Thus, 13 patients completed the protocol.
▪ Interventions: Women ate yogurt for 6 months of the study period.
▪ Measurements: Colonization of lactobacilli and Candida in the vagina and rectum; candidal infections of the vagina.
▪ Main Results: Thirty-three eligible patients were studied. A threefold decrease in infections was seen when patients consumed yogurt containing Lactobacillus acidophilus. The mean (± SD) number of infections per 6 months was 2.54 ± 1.66 in the control arm and 0.38 ± 0.51 per 6 months in the yogurt arm (P = 0.001). Candidal colonization decreased from a mean of 3.23 ± 2.17 per 6 months in the control arm to 0.84 ± 0.90 per 6 months in the yogurt arm (P = 0.001).
▪ Conclusion: Daily ingestion of 8 ounces of yogurt containing Lactobacillus acidophilus decreased both candidal colonization and infection.
Eileen Hilton, Henry D. Isenberg, Phyllis Alperstein, Kenneth France, Michael T. Borenstein. Ingestion of Yogurt Containing Lactobacillus acidophilus as Prophylaxis for Candidal Vaginitis. Ann Intern Med. 1992;116:353–357. doi: 10.7326/0003-4819-116-5-353
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Published: Ann Intern Med. 1992;116(5):353-357.
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