Pascal Chazerain, MD; Olivier Meyer, MD; Marcel-Francis Kahn, MD
To the Editors: We read with great interest the article by Ronnblom and colleagues (1) describing the development of autoimmune diseases after alpha-interferon therapy for malignant carcinoid tumors. We extend the scope of alpha-interferon-induced autoimmune diseases by reporting the cases of three patients with rheumatoid arthritis-like disease.
Two men and one woman (64, 52, and 42 years of age, respectively) with chronic myeloproliferative disorders (two patients) and chronic active autoimmune hepatitis (one patient) developed symptoms and signs consistent with acute (one patient) or chronic (two patients) polyarthritis during treatment with recombinant alpha-interferon (alpha-2a, Roferon, Roche, Nutley, New Jersey; or alpha-2b,
Chazerain P, Meyer O, Kahn M. Rheumatoid Arthritis-like Disease after Alpha-Interferon Therapy. Ann Intern Med. 1992;116:427. doi: 10.7326/0003-4819-116-5-427_1
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Published: Ann Intern Med. 1992;116(5):427.
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