John Rex, MD
To the Editors: Itraconazole, a triazole derivative of ketoconazole, has shown substantial promise as therapy for fungal infections (1). Interactions between itraconazole and cyclosporine, phenytoin, rifampin, and carbamazepine have been reported (2, 3), and our experience suggests that an interaction also occurs between itraconazole and digoxin.
A 68-year-old man developed right elbow swelling, and Sporothrix schenckii osteoarthritis was diagnosed after joint debridement. After month-long trials of SSKI (saturated solution of potassium iodide) and then ketoconazole (200 mg bid) failed to improve his joint, he was referred to us. The patient's past medical history was pertinent for atrial fibrillation, which had
Rex J. Itraconazole-Digoxin Interaction. Ann Intern Med. ;116:525. doi: 10.7326/0003-4819-116-6-525
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Published: Ann Intern Med. 1992;116(6):525.
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