Nortin M. Hadler, MD
Osteoarthritis is a well-defined pathoanatomic entity readily demonstrable by modern imaging techniques. For a century, the pathology that is this disease has been ingrained in the mind of every medical student: inexorable progression from subtle biochemical alterations in articular cartilage through cartilage loss and reactive bone formation to the end-stage of eburnated bone and exuberant osteophytosis. We all shudder at the image of the patient suffering with end-stage osteoarthritis, bedeviled by a deformed, unstable, incapacitating, and painful knee. What physician can listen to the complaint of knee pain without conjuring up the image of such an outcome? What physician can
Hadler NM. Knee Pain Is the Malady—Not Osteoarthritis. Ann Intern Med. ;116:598–599. doi: 10.7326/0003-4819-116-7-598
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Published: Ann Intern Med. 1992;116(7):598-599.
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