Irving E. Salit, MD, CM
To the editors: Palestine and colleagues (1) examined the role of foscarnet in the treatment of cytomegalovirus retinitis in the acquired immunodeficiency syndrome (AIDS). They conducted a randomized, controlled trial in which the patients in one study arm initially received no treatment. What was the rational for having such a control group? Cytomegalovirus retinitis is the most common intraocular infection and the most common cause of blindness in patients with AIDS. Both ganciclovir and foscarnet have been shown to be approximately 90% effective in arresting retinitis, at least during the induction phase (2-4). It is also well known that, despite
Salit IE. Why Was Treatment of Cytomegalovirus Retinitis Randomized?. Ann Intern Med. ;116:604–605. doi: 10.7326/0003-4819-116-7-604
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Published: Ann Intern Med. 1992;116(7):604-605.
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