Patrice Cacoub, MD; Françoise Lunel-Fabiani, MD, PhD; Le Thi Huong Du, MD
To the editors: Markers of hepatitis B virus (HBV) infection have been reported in 20% to 40% of patients with polyarteritis nodosa, suggesting that HBV could be an etiologic factor (1-3). Infection with hepatitis C virus (HCV), a recently characterized RNA virus, is responsible for chronic hepatitis and liver cirrhosis and is frequently associated with HBV infection (4). Our aim was to assess the prevalence of HCV markers in patients with polyarteritis nodosa.
To avoid bias due to false-positive reactions with a second-generation enzyme-linked immunosorbent assay (ELISA 2) (Ortho HCV ELISA Test System 2nd Generation, Ortho Diagnostic Systems, Raritan, New
Cacoub P, Lunel-Fabiani F, Huong Du LT. Polyarteritis Nodosa and Hepatitis C Virus Infection. Ann Intern Med. 1992;116:605–606. doi: 10.7326/0003-4819-116-7-605_2
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Published: Ann Intern Med. 1992;116(7):605-606.
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