Ellen J. Mangione, MD, MPH; John M. Douglas, MD
To the Editors: The results of a recent study conducted by Chow and colleagues (1) indicated that newer-generation cephalosporins should be used cautiously in treating Enterobacter bacteremias. They showed an associated higher risk for subsequent infection with a strain that is resistant to multiple beta-lactam antibiotics and the greater mortality associated with these strains (1).
Although Chow and coworkers (1) showed a relation between presence in the intensive care unit at time of the initial blood culture and mortality, they did not explore the potentially important relation between hospitalization in the intensive care unit and use of newer cephalosporins. These
Mangione EJ, Douglas JM. Antibiotic-resistant Enterobacter and the Newer Cephalosporins. Ann Intern Med. ;116:700–701. doi: 10.7326/0003-4819-116-8-700
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Published: Ann Intern Med. 1992;116(8):700-701.
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