John H. Walsh, MD
Helicobacter pylori (formerly called Campylobacter pylori) has been shown to infect the gastric mucus layer of almost all patients with duodenal ulcer disease, most patients with gastric ulcer disease, and almost all patients with histologic antral gastritis (1, 2). Its role in the pathogenesis of peptic ulcer disease and gastritis has been suggested by the findings that bacterial eradication markedly decreases duodenal ulcer recurrence rates (3, 4), reverses histologic gastritis (5), and may hasten healing of active duodenal ulcers (6). Antibacterial treatment and acid suppression are two effective approaches to the prevention of ulcer recurrence with different pathogenic mechanisms.
John H. Walsh. Helicobacter pylori: Selection of Patients for Treatment. Ann Intern Med. 1992;116:770–771. doi: 10.7326/0003-4819-116-9-770
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Published: Ann Intern Med. 1992;116(9):770-771.
Gastroenterology/Hepatology, H. Pylori, Infectious Disease, Peptic Disease.
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