Hamid Sahebjami, MD
To the Editors: Reports of emphysema-like changes in the lungs of human immunodeficiency virus (HlV)-infected patients, as in the cases reported by Diaz and colleagues (1), are very intriguing because they occur in young and middle-aged persons, some with no history of lung disease or smoking. What is missing is information about the nutritional status of these patients. We reported in 1981 that food restriction alters lung structure and function in experimental animals and leads to morphologic, morphometric, and physiologic changes similar to those known to occur in emphysema (2). Subsequent reports from other laboratories confirmed our findings, and this
Sahebjami H. Emphysema-like Changes in HIV. Ann Intern Med. ;116:876. doi: 10.7326/0003-4819-116-10-876_1
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Published: Ann Intern Med. 1992;116(10):876.
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