James P. Dunn, MD; Douglas A. Jabs, MD
To the Editors: Bernauer and colleagues (1) reported cotton-wool spots in 13% of bone marrow transplant recipients who were treated with both cyclosporine A and total body irradiation, compared with 0% in patients who were treated with one or the other. In addition, 3% of patients in the former group developed bilateral optic disc edema. This condition was associated with moderate-to-severe visual field damage, including arcuate defects, which were entirely or partly reversible in all patients. The investigators used the term "ischemic fundus lesion" to describe both cotton-wool spots and optic disc edema.
Optic disc edema has many causes, including
Dunn JP, Jabs DA. Ocular Microvasculopathy after Bone Marrow Transplantation. Ann Intern Med. ;116:956–957. doi: 10.7326/0003-4819-116-11-956
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Published: Ann Intern Med. 1992;116(11):956-957.
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