Steven J. Sperber, MD; J. Owen Hendley, MD; Frederick G. Hayden, MD; Donald K. Riker, PhD; James V. Sorrentino, PhD; Jack M. Gwaltney Jr., MD
▪ Objective: To determine whether naproxen, a propionic acid inhibitor of cyclooxygenase, alters the course of experimental rhinovirus colds.
▪ Design: A randomized, double-blind, controlled trial.
▪ Setting: Rhinovirus challenge model in volunteers cloistered in individual hotel rooms.
▪ Volunteers: Eighty-seven healthy young adults with serum neutralizing antibody titers of ≤ 1:2 to the challenge virus; 79 were evaluable.
▪ Intervention: Thirty-nine participants received naproxen (loading dose, 400 mg or 500 mg followed by 200 mg or 500 mg three times daily for 5 days). Forty participants received placebo. Treatment was started 6 hours after viral challenge.
▪ Measurements: Daily measurement of viral titers, symptoms, nasal mucus production, and nasal tissue use; incidence of infection and illness; and measurement of homotypic serum neutralizing antibody responses.
▪ Results: Viral titers and serum homotypic antibody responses were similar in the naproxen and placebo groups. Significant reductions in headache, malaise, myalgia, and cough occurred in the naproxen group. A 29% reduction was noted in the total (5-day) symptom score in the naproxen group (95% Cl, 16% to 42%).
▪ Conclusion: Naproxen treatment did not alter virus shedding or serum neutralizing antibody responses in participants with experimental rhinovirus colds, but it had a beneficial effect on the symptoms of headache, malaise, myalgia, and cough. Prostaglandins may be among the inflammatory mediators that play a role in the pathogenesis of rhinovirus colds.
Sperber SJ, Hendley JO, Hayden FG, Riker DK, Sorrentino JV, Gwaltney JM. Effects of Naproxen on Experimental Rhinovirus Colds: A Randomized, Double-Blind, Controlled Trial. Ann Intern Med. ;117:37–41. doi: 10.7326/0003-4819-117-1-37
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Published: Ann Intern Med. 1992;117(1):37-41.
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