Luis C. Ramirez, MD; Carlos Arauz-Pacheco, MD; Carolin Lackner, MD; George Albright, BA; Beverly V. Adams, MS; Philip Raskin, MD
▪ Objective: To determine the influence of diabetes control on serum lipoprotein (a) concentrations.
▪ Setting: Diabetes clinic of a large metropolitan public hospital, with primary- and secondary-care patients.
▪ Design: A cross-sectional study. Comparisons of lipoprotein (a) concentrations were made between a normal control group, a group of diabetic patients with glycated hemoglobin (HbA1c) less than 8.0%, and a group of diabetic patients with HbA1c of 8.0% or higher.
▪ Patients: Ninety-five normal controls and 93 diabetic subjects (49 with insulin-dependent diabetes mellitus and 44 with noninsulin-dependent diabetes mellitus).
▪ Results: Sixty diabetic subjects with HbA1c levels of 8.0% or higher had higher (25 mg/dL) median levels of lipoprotein (a) when compared with either 93 normal controls (8.8 mg/dL) or 33 diabetic patients with HbA1c less than 8.0% (7.5 mg/dL) (P = 0.008 and P = 0.012, respectively). A similar pattern of distribution of lipoprotein (a) levels according to degree of metabolic control was seen in patients with insulin-dependent diabetes mellitus and noninsulin-dependent diabetes mellitus. No difference in the lipoprotein (a) distribution was noted between diabetic men and women. No correlation was observed between lipoprotein (a) levels and total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels.
▪ Conclusion: Lipoprotein (a) levels are elevated in poorly controlled diabetic patients. Increased levels of lipoprotein (a) may be a contributing factor to the high risk for atherosclerosis observed in diabetic patients.
Ramirez LC, Arauz-Pacheco C, Lackner C, Albright G, Adams BV, Raskin P. Lipoprotein (a) Levels in Diabetes Mellitus: Relationship to Metabolic Control. Ann Intern Med. ;117:42–47. doi: 10.7326/0003-4819-117-1-42
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Published: Ann Intern Med. 1992;117(1):42-47.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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