Margaret M. Redfield, MD; Walter J. Nicholson, MD; William D. Edwards, MD; A. Jamil Tajik, MD
Ergot alkaloid preparations such as ergotamine (Cafergot, Sandoz, East Hanover, New Jersey) and methysergide (Sansert, Sandoz) are used to treat migraine headache. Characteristic histologic changes are seen in patients with methysergide-induced valvular disease (primarily mitral and aortic regurgitation) (1, 2). Recently, ergotamine-induced valvular disease was documented pathologically (3). We report the echocardiographic and pathologic features of five patients with valvular disease associated with long-term ingestion of ergot alkaloids.
All patients were using ergot alkaloid preparations for treatment of headache. Patients were initially identified because gross pathologic findings were thought to be unusually severe for rheumatic disease. The
Margaret M. Redfield, Walter J. Nicholson, William D. Edwards, A. Jamil Tajik. Valve Disease Associated with Ergot Alkaloid Use: Echocardiographic and Pathologic Correlations. Ann Intern Med. 1992;117:50–52. doi: 10.7326/0003-4819-117-1-50
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Published: Ann Intern Med. 1992;117(1):50-52.
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