Sonya Vaziri, MD; Mahesh Bikkina, MD; Daniel Levy, MD
To the Editors: In their recent analysis, the Stroke Prevention in Atrial Fibrillation (SPAF) investigators (1) concluded that a history of hypertension, recent congestive heart failure, and previous thromboembolism are important clinical features that identify patients with nonrheumatic atrial fibrillation at high risk for thromboembolism. The therapeutic implications of this analysis deserve comment. Sixty-three percent of the patients were in the warfarin-ineligible, placebo arm of the study, and the remainder of the patients were drawn from the warfarin-eligible, placebo arm. Thus, conclusions about the value of prophylactic anticoagulant therapy (but not antiplatelet therapy) in this study sample are unclear. Analysis
Vaziri S, Bikkina M, Levy D. Predictors of Thromboembolism in Atrial Fibrillation. Ann Intern Med. ;117:89–90. doi: 10.7326/0003-4819-117-1-89
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Published: Ann Intern Med. 1992;117(1):89-90.
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