Michael Bursztyn, MD
To the Editors: Chapman and colleagues (1) described a situation where renal ischemia may bring about reversible acute renal failure when challenged with angiotensin-converting enzyme (ACE) inhibitors—the case of autosomal-dominant polycystic kidney disease (ADPKD) with massive cystic involvement, mostly concomitant with diuretic treatment. Over the years, I have treated with ACE inhibitors several ADPKD patients with mild renal insufficiency and hypertension who did not show such untoward effects; I wonder how frequently Chapman and coworkers encountered this complication. This finding is important in determining the relative risk for such a complication. Are Chapman and colleagues suggesting that we should refrain
Bursztyn M. Polycystic Kidney Disease and Angiotensin-converting Enzyme Inhibitors. Ann Intern Med. ;117:90. doi: 10.7326/0003-4819-117-1-90_1
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Published: Ann Intern Med. 1992;117(1):90.
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