B. Clotet, MD; J. Romeu, MD; G. Sirera, MD
To the Editors: Recently, Heald and coworkers (1) focused on the decreased risk in acquired immunodeficiency syndrome (AIDS) patients for developing subsequent Pneumocystis carinii pneumonia after being treated for cerebral toxoplasmosis. According to these authors, "decreased risk is probably the result of chronic suppressive treatment with pyrimethamine and sulfonamides."
We would like to point out that the reverse is also true for patients receiving primary or secondary prophylaxis for P. carinii pneumonia. We have reported that primary toxoplasmosis did not occur in 54 human immunodeficiency virus (HIV)-positive patients (26 had AIDS, and 28 belonged to stage IV-C2); these patients had
Clotet B, Romeu J, Sirera G. Cerebral Toxoplasmosis and Prophylaxis for Pneumocystis carinii Pneumonia. Ann Intern Med. ;117:169. doi: 10.7326/0003-4819-117-2-169_1
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Published: Ann Intern Med. 1992;117(2):169.
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