David L. Hahn, MD
To the Editors: Saikku and colleagues (1) present evidence of an association between chronic Chlamydia pneumoniae infection and the development of coronary heart disease in the Helsinki Heart Study. This association, if confirmed, could have a profound effect on the prevention and management of coronary heart disease. The odds ratios associating evidence of C. pneumoniae infection and coronary heart disease were attenuated (from 2.7 to 2.3 for immunoglobulin A [IgA] titers, 2.1 to 1.8 for immune complexes, and 2.9 to 2.6 for the presence of both factors). There was no statistical difference for IgA titers and immune complexes after controlling
Hahn DL. Chlamydia, Smoking, and Heart Disease. Ann Intern Med. 1992;117:171. doi: 10.7326/0003-4819-117-2-171_1
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Published: Ann Intern Med. 1992;117(2):171.
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