Samir K. Ballas, MD; Ronald N. Rubin, MD; Thomas C. Gabuzda, MD
To the Editors: We read with interest the article by Brookoff and Polomano (1) about treating sickle cell pain like cancer pain. This concept is not new (2). Sickle cell disease is heterogeneous and varies from very mild to very severe. The exact diagnosis of the patients studied and their fetal hemoglobin (Hb F) level were not mentioned by Brookoff and Polomano. Patients with sickle cell anemia or sickle-β0;-thalassemia tend to have more frequent painful crises than patients with sickle cell Hb disease or sickle-β+-thalassemia (3). Moreover, several factors may moderate the severity of sickle cell anemia (3, 4). Patients
Ballas SK, Rubin RN, Gabuzda TC. Treating Sickle Cell Pain like Cancer Pain. Ann Intern Med. ;117:263–265. doi: 10.7326/0003-4819-117-3-263
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Published: Ann Intern Med. 1992;117(3):263-265.
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