Barry I. Freedman, MD; Eugene R. Heise, PhD; Vincent J. Canzanello, MD
To the Editors: The identification of an HLA-DR3/4 phenotype association with diabetes mellitus-induced autonomic neuropathy is an important advance in the demonstration of a genetic basis for specific target organ involvement in diabetes (1). We have previously reported race-controlled HLA phenotype frequencies in renal failure induced by insulin-dependent diabetes mellitus (2) and in hypertension (3). The HLA-DR3 and DR4 antigens were the ones most strongly associated with diabetic nephropathy in both blacks and whites. Frequency of HLA-DR3 was increased in blacks with hypertension-induced renal failure. Inter-racial analyses showed HLA-A1 and DR3 frequencies were increased in whites, compared with blacks, with
Freedman BI, Heise ER, Canzanello VJ. Diabetic Neuropathy and HLA-DR3/4. Ann Intern Med. ;117:445. doi: 10.7326/0003-4819-117-5-445_1
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Published: Ann Intern Med. 1992;117(5):445.
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