Jana Havrankova, MD; Raymond Lahaie, MD
To the Editors: Sucralfate is widely used in gastrointestinal ulcer therapy and as a cytoprotective agent in patients receiving anti-inflammatory agents. Because prevalence of hypothyroidism varies from 0.5% to 4%, physicians may see patients who have been treated with both levothyroxine and sucralfate. We examined a 63-year-old woman taking sucralfate, whose hypothyroidism (secondary to radioiodine treatment for diffuse toxic goiter given 8 months earlier) could not be corrected despite administration of up to 4.8 µg/kg body weight of levothyroxine, three times the usual replacement dose. When levothyroxine was taken 2.5 hours after sucralfate, the plasma thyroid-stimulating hormone (TSH) level remained
Havrankova J, Lahaie R. Levothyroxine Binding by Sucralfate. Ann Intern Med. ;117:445–446. doi: 10.7326/0003-4819-117-5-445_3
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Published: Ann Intern Med. 1992;117(5):445-446.
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