Leonid Poretsky, MD
To the Editors: LeRoith and colleagues (1) could have added to their discussion of insulin-like growth factors (IGFs) in health and disease yet another organ in which the physiologic, pathophysiologic, and therapeutic importance of IGFs has been shown. Physiologically, ovaries produce various growth factors, including IGFs, that are important for normal follicular development (2). Ovaries also possess receptors for IGFs (3).
Pathologically, IGF-I receptors are the likely mediators of insulin-induced hyperandrogenism, which is commonly observed in insulin-resistant patients (3). In addition to stimulating androgen production, hyperinsulinemia appears to upregulate ovarian IGF-I receptors, which further enhances this "alternate" pathway for insulin
Poretsky L. Ovarian Insulin-like Growth Factors. Ann Intern Med. ;117:535. doi: 10.7326/0003-4819-117-6-535_1
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Published: Ann Intern Med. 1992;117(6):535.
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